(2S,4R)-2-(hydroxymethyl)-4-[(methylsulfonyl)oxy]-1-Pyrrolidinecarboxylic acid,(4-nitrophenyl)methyl ester
1-Pyrrolidinecarboxylic acid, 2-(hydroxymethyl)-4-[(methylsulfonyl)oxy]-, (4-nitrophenyl)methyl ester, (2S,4R)-
CAS: 127626-37-3
Molecular Formula: C14H18N2O8S
(2S,4R)-2-(hydroxymethyl)-4-[(methylsulfonyl)oxy]-1-Pyrrolidinecarboxylic acid,(4-nitrophenyl)methyl ester - Names and Identifiers
(2S,4R)-2-(hydroxymethyl)-4-[(methylsulfonyl)oxy]-1-Pyrrolidinecarboxylic acid,(4-nitrophenyl)methyl ester - Physico-chemical Properties
| Molecular Formula | C14H18N2O8S |
| Molar Mass | 374.37 |
| Density | 1.51 |
| Melting Point | 113-116℃ |
| Storage Condition | 2-8°C |
| Sensitive | IRRITANT |
| MDL | MFCD18800446 |
(2S,4R)-2-(hydroxymethyl)-4-[(methylsulfonyl)oxy]-1-Pyrrolidinecarboxylic acid,(4-nitrophenyl)methyl ester - Introduction
(2S,4R) 1-pyrrolidinecarboxylic acid is an organic compound whose chemical formula is C6H9NO2. The following is a description of the properties, uses, preparation and safety information of (2S,4R) 1-pyrrolidine carboxylic acid:
Nature:
-Appearance: Colorless or white crystalline powder;
-Solubility: soluble in water and common organic solvents;
-Melting point: about 150-155°C.
Use:
-as a drug intermediate:(2S,4R) 1-pyrrolidine carboxylic acid can be used to synthesize a variety of drug intermediates, such as antitumor drugs, antiviral drugs, antiepileptic drugs, etc;
-as a chiral catalyst:(2S,4R) 1-pyrrolidine carboxylic acid can catalyze a variety of chiral organic reactions, such as asymmetric synthesis, Friedel-Crafts reaction, etc.
Preparation Method:
The preparation method of (2S,4R) 1-pyrrolidine carboxylic acid can be achieved by the following steps:
1. reacting 4-amino -1-phenyl -2-carbonyl pyrrolidine with p-iodomethane to obtain 4-(methylamino)-1-phenyl -2-carbonyl pyrrolidine (4-methyl amino phenyl pyrrolidone);
2. 4-Methylaminophenylpyrrolidone is reduced with a base to obtain (2S,4R) 1-pyrrolidinecarboxylic acid.
Safety Information:
The specific safety and toxicity information for (2S,4R) 1-Pyrrolidine carboxylic acid may be affected by factors such as the manufacturing process, so it is best to follow the following safety precautions when using or coming into contact with this compound:
-Wear appropriate personal protective equipment, such as lab gloves and goggles, when handling the compound;
-Avoid inhaling the dust or smell of the compound and ensure that you work in a well-ventilated area;
-During use or storage, comply with relevant safety procedures to avoid unsafe reactions with other substances.
Nature:
-Appearance: Colorless or white crystalline powder;
-Solubility: soluble in water and common organic solvents;
-Melting point: about 150-155°C.
Use:
-as a drug intermediate:(2S,4R) 1-pyrrolidine carboxylic acid can be used to synthesize a variety of drug intermediates, such as antitumor drugs, antiviral drugs, antiepileptic drugs, etc;
-as a chiral catalyst:(2S,4R) 1-pyrrolidine carboxylic acid can catalyze a variety of chiral organic reactions, such as asymmetric synthesis, Friedel-Crafts reaction, etc.
Preparation Method:
The preparation method of (2S,4R) 1-pyrrolidine carboxylic acid can be achieved by the following steps:
1. reacting 4-amino -1-phenyl -2-carbonyl pyrrolidine with p-iodomethane to obtain 4-(methylamino)-1-phenyl -2-carbonyl pyrrolidine (4-methyl amino phenyl pyrrolidone);
2. 4-Methylaminophenylpyrrolidone is reduced with a base to obtain (2S,4R) 1-pyrrolidinecarboxylic acid.
Safety Information:
The specific safety and toxicity information for (2S,4R) 1-Pyrrolidine carboxylic acid may be affected by factors such as the manufacturing process, so it is best to follow the following safety precautions when using or coming into contact with this compound:
-Wear appropriate personal protective equipment, such as lab gloves and goggles, when handling the compound;
-Avoid inhaling the dust or smell of the compound and ensure that you work in a well-ventilated area;
-During use or storage, comply with relevant safety procedures to avoid unsafe reactions with other substances.
Last Update：2024-04-09 21:32:37
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Spot supply
Product Name: (2S,trans)-4-Nitrobenzyl 2-(hydroxymethyl)-4-((methylsulfonyl)oxy)pyrrolidine-1-carboxylate Visit Supplier Webpage Request for quotationCAS: 127626-37-3
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View History
(2S,4R)-2-(hydroxymethyl)-4-[(methylsulfonyl)oxy]-1-Pyrrolidinecarboxylic acid,(4-nitrophenyl)methyl ester
1-(3,5-Dichloro-phenyl)-cyclopropylamine
3,4-METHYLENEDIOXYBENZOIC ACID HYDRAZIDE
2-(1-ethoxypropoxy)ethen-1-one
Methyl phenylacetate
1460-05-5
2200-70-6
2208-15-3
1762-95-4
291-64-5
1-(3,5-Dichloro-phenyl)-cyclopropylamine
3,4-METHYLENEDIOXYBENZOIC ACID HYDRAZIDE
2-(1-ethoxypropoxy)ethen-1-one
Methyl phenylacetate
1460-05-5
2200-70-6
2208-15-3
1762-95-4
291-64-5